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Molecular genetics of bacteria Item Preview. EMBED for wordpress. Want more? Advanced embedding details, examples, and help! Molecular Genetics of Bacteria presents both the basic concepts and the most exciting recent developments in a form which is suitable for the needs of students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences.
The structure of the third edition has undergone a major reorganization and incorporates: new material on the concept of adaptive mutation, bacterial differentiation, intercellular signalling, conjugative transposons and integrons; enhanced coverage of supercoiling, reporter genes, sporulation, PCR and genome sequencing projects.
Nucleic Acid Structure and Function -- Ch. Mutation and Variation -- Ch. Regulation of Gene Expression -- Ch. Genetics of Bacteriophages -- Ch. True, many of the older methods are now no longer used, and could be relegated to the pages of history. But there is a danger of throwing out the baby with the bathwater. Not only is there a need to maintain some sense of how the subject has got to the stage we are now at, but also a discussion of some of these methods is useful in establishing an understanding of how bacterial genetics operates in natural environments.
Molecular genetics, in isolation, is essentially reductionist. Even genome sequencing, and global analysis of gene expression, by themselves merely provide catalogues of genes. Ultimately, those lists have to be related to the behaviour of the whole organism, and from there to how organisms interact with one another and with their environment.
So we have continued with a compromise approach, slimming down even further the description of classical bacterial genetics to allow space not only for some of the new technological advances but also for some of the advances that these methods have allowed in understanding important aspects of bacterial behaviour.
One further aspect needs a word of explanation. What is a bacterium? It is now clear that there are two distinct types of prokaryote: the bacteria proper and the Archea. Most of this book concerns the bacteria in the proper taxonomic sense, but some aspects are also relevant to Archea, especially where we consider the differences between prokaryotes and eukaryotes. It complicates the text too much to make this distinction, so we apologize if anyone is offended by occasional blurring of the lines between bacteria and prokaryotes.
As with the earlier editions, the choice of what to include and what to leave out is very much a personal one. In this book it is assumed that you will already have a working knowledge of the essentials of molecular biology, especially the structure and synthesis of nucleic acids and proteins. The purpose of this chapter therefore is to serve as a reminder of some of the most relevant points, and to highlight those features that are particularly essential for an understanding of later chapters.
The components of DNA Figure 1. The sugar residues are linked by phosphodiester bonds between the 5 position of one deoxyribose and the 3 position of the next Figure 1. It is the sequence of these four bases that carries the genetic information. The two strands are twisted around each other in the now familiar double helix, with the bases in the centre and the sugar-phosphate backbone on the outside. The two strands are linked by hydrogen bonds between the bases.
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